Apparatus and method for joining two guide wire core materials without a hypotube

ABSTRACT

An intravascular guide wire having at least two core materials joined together without the use of a hypotube. There is a core having a proximal core section with a proximal end and a distal end and a distal core section with a proximal end and a distal end. The distal end of the proximal core section and the proximal end of the distal core section are ground into complementary shapes, and then placed into a fixture in opposing directions with a small gap in-between the ends to receive a mass of hardened material to wick therein. Once the proximal and distal core sections are bonded, welded, brazed, cemented, or soldered together, the guide wire is then ground to a required outer diameter, depending on the design needs of the specific guide wire.

BACKGROUND OF THE INVENTION

[0001] This invention relates to the field of medical devices, and moreparticularly to a guide wire for advancing a catheter within a bodylumen in a procedure such as percutaneous transluminal coronaryangioplasty (PTCA).

[0002] In a typical PTCA procedure, a guiding catheter having apre-formed distal tip is percutaneously introduced into a patient'speripheral artery, e.g. femoral or brachial artery, by means of aconventional Seldinger technique and advanced therein until the distaltip of the guiding catheter is seated in the ostium of a desiredcoronary artery. A guide wire is first advanced by itself through theguiding catheter until the distal tip of the guide wire extends beyondthe arterial location where the procedure is to be performed. Then acatheter is mounted onto the proximal portion of the guide wire whichextends out of the proximal end of the guiding catheter which is outsideof the patient. The catheter is advanced over the guide wire, while theposition of the guide wire is fixed, until the operative element on thecatheter is disposed within the arterial location where the procedure isto be performed. After the procedure is performed, the catheter may bewithdrawn from the patient over the guide wire or the guide wirerepositioned within the coronary anatomy for an additional procedure.

[0003] Conventional guide wires for angioplasty, stent delivery,atherectomy and other intravascular procedures usually have an elongatecore member with one or more segments near the distal end thereof whichtaper distally to smaller cross sections. A flexible body member, suchas a helical coil or a tubular body of polymeric material, is typicallydisposed about and secured to at least part of the distal portion of thecore member. A shaping member, which may be the distal extremity of thecore member or a separate shaping ribbon which is secured to the distalextremity of the core member, extends through the flexible body and issecured to the distal end of the flexible body by soldering, brazing orwelding; or an adhesive may be used in the case of polymeric flexiblebodies which forms a rounded distal tip. The leading tip is highlyflexible and will not damage or perforate the vessel. The portion behindthe distal tip is increasingly stiff, which better supports a ballooncatheter or similar device.

[0004] A major requirement for guide wires is that they have sufficientcolumn strength to be pushed through a patient's vascular system orother body lumen without kinking. However, they must also be flexibleenough to avoid damaging the blood vessel or other body lumen throughwhich thy are advanced. Efforts have been made to improve both thestrength and flexibility of guide wires to make them more suitable fortheir intended uses, but these two properties are for the most partdiametrically opposed to one another in that an increase in one usuallyinvolves a decrease in the other.

[0005] In order to fulfill these requirements, guide wires now includetwo different types of material joined together with a connecting tube,hypotube, or sleeve, so that a proximal core will consist of a materialhaving sufficient column strength and a distal core will be made of aflexible material to advance through a body lumen. Currently, anexpensive nitinol hypotube or connecting tube is used to join a proximalstainless steel core to a nitinol distal core on certain types of guidewires. An example of this type of guide wire can be seen in, forexample, U.S. Pat. No. 6,248,082 (Jafari).

SUMMARY OF THE INVENTION

[0006] The present invention is directed to an intravascular guide wirehaving at least two core materials joined together without the use of ahypotube. In one embodiment, the invention provides a core having aproximal core section with a proximal end and a distal end and a distalcore section with a proximal end and a distal end. It is preferred thatthe proximal core section is made of stainless steel to providesufficient column strength, and the distal core section is made ofnitinol which is flexible to advance through a tortuous body lumen. Thedistal end of the proximal core section and the proximal end of thedistal core section are formed into a complementary shapes, and thenplaced into a fixture in opposing directions with a small gap in-betweenthe ends. The small gap allows for a mass of hardened material to wicktherein. Once the proximal and distal core sections are bonded together,the guide wire is ground to a required outer diameter depending on thedesign needs of the specific guide wire.

[0007] The geometric design of the distal end of the proximal core andthe proximal end of the distal core (“the connecting ends”) can beconstructed using a variety of methods and can be shaped in a variety ofdesigns. The methods for forming the complementary geometric shapes intothe connecting ends include, but are not limited to, grinding, milling,electrical discharge machining (EDM), laser cutting, etc. Designs of theconnecting ends can include a D-shape cross-sectional shape, or aD-shape cross-sectional shape with a backside of one of the connectingends including a taper. Another embodiment includes a D-shapecross-sectional shape with a serration, and a taper may be added to thebackside of this design as well. Yet another embodiment includes atapered D-shaped cross-sectional shape. The connecting ends may alsohave locking serrations, where the locking serrations of the endsmechanically grip, clasp, or engage one another. These and othercomplementary interfacing shapes may be used at the connecting ends.

[0008] The mass of hardened material that is used to join the proximaland distal cores may be any bonding material, including the following:solder, brazes, epoxies, glues, laser welds, spot welds, etc. that arepreferable for the wire type and provide the required functionalattributes. Joining the two cores together can be accomplished bydispensing, for example, solder in-between the connecting ends and/orencasing the connecting ends with solder.

[0009] The present invention method of joining a proximal and a distalcore section can be applied to any two wires, and to any guide wirehaving a diameter ranging from about 0.006 to 0.040 inch. Wire materialsthat may be combined through this method include, but are not limitedto, all types of metals, alloys, polymers, and composite materials.

[0010] The present invention can also be used to create a guide wirewith two lap joints. One joint would connect the proximal core sectionto the distal core section, and the second joint would connect a shapingribbon to the distal end of the distal core section.

[0011] These and other advantages of the invention will become moreapparent from the following detailed description thereof and theaccompanying exemplary drawings.

BRIEF DESCRIPTION OF THE DRAWINGS

[0012]FIG. 1 is a side elevational view showing one embodiment of thepresent invention guide wire with two sections connected without the useof a hypotube.

[0013]FIG. 2 is a partial perspective view of the tip of a D-shapeddistal end of one of the core sections of the guide wire.

[0014]FIG. 3 is a partial, side elevational view depicting thecomplementary distal end of the proximal core section and the proximalend of the distal core section, aligned with one another with a gaptherebetween.

[0015]FIG. 4 is a partial, side elevational view of the guide wire shownin FIG. 3 with the outer diameter having been ground down.

[0016]FIG. 5 is a partial, side elevational view of the guide wire inFIG. 3 with tapered backsides.

[0017]FIG. 6 is a partial, side elevational view of the distal end ofthe proximal core section and the proximal end of the distal coresection having a tapered D-shape.

[0018]FIG. 7 is a partial, side elevational view of the distal end ofthe proximal core section and the proximal end of the distal coresection wherein the interfacing surfaces are serrated.

[0019]FIG. 8 is a partial, side elevational view of the guide wire inFIG. 7 with a tapered backside.

[0020]FIG. 9 is a partial, side elevational view of the distal end ofthe proximal core section and the proximal end of the distal coresection wherein the interfacing surfaces have locking serrations.

[0021]FIG. 10 is a cross-sectional view taken along line 10-10 in FIG. 3showing the distal end of the proximal core section and the proximal endof the distal core section encased in solder.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

[0022] The present invention is directed to a guide wire that uses atleast two core materials that are joined at an interface without the useof a sleeve or hypotube at the joint. FIG. 1 illustrates in a sideelevational view one embodiment of the present invention guide wire,generally designated 20, that is adapted for insertion into a patient'sbody lumen, such as an artery or vein. In this embodiment, theintravascular guide wire 20 has at least two core materials joined orsecured together without the use of a hypotube, connecting tube, orsleeve. In particular, the guide wire 20 has a core 22 with a proximalcore section 24 having a proximal end 26 and a distal end 28 and adistal core section 30 having a proximal end 32 and a distal end 34. Itis preferred that the proximal core section 24 is made of stainlesssteel, and the distal core section 30 is made of nitinol. However, thecore sections may be made out of any material known in the guide wireart.

[0023] In the embodiment as shown in FIG. 1, the guide wire 20 alsoincludes a shapeable member 70 which can be secured to the distal end 30by a solder or weld bead 82, and a flexible body 72 such as a helicalcoil. Preferably, the flexible body 72 is disposed about and secured tothe distal core section 30 by a solder or weld bead 84. The distal coresection 30 has an optional tapered core segment 74 and an optionalflexible core segment 76 which is distally contiguous to the taperedcore segment. At the very distal end of the flexible core segment 76 isa rounded distal extremity 78. Of course, the rounded distal extremity78 may be of other shapes and sizes, can be flattened, or omittedaltogether. In fact, in an alternative embodiment core-to-tip design,the core segment 76 extends continuously to engage a rounded tip 80 atthe very distal end of the guide wire 20.

[0024] The distal end 28 of the proximal core section 24 and theproximal end 32 of the distal core section 30, now referred to as theconnecting ends 28 and 32, are aligned with one another. The connectingends 28, 32 have complementary shapes as seen in FIG. 3. That is, in theembodiment shown, the connecting ends 28, 32 have respective elongatedcut-outs or chamfers that engage each other. The complementary cut-outsprovide a constant, low profile outside diameter along the joint.Moreover, the elongated overlap at the joint presents a large surfacearea for a bond, weld, etc. to adhere to thus improving the strength ofthe joint. Furthermore, the large overlap ensures efficient torquetransmission from the proximal core section 24 to the distal coresection 30.

[0025] A mass of hardened material 36 disposed between the connectingends 28, 32, and/or encase the connecting ends. The mass of hardenedmaterial 36 is a bonding material such as, but not limited to, solders,brazes, epoxies, glues, welds including laser welds and spot welds. Itis preferred that solder is used to form a joint between the connectingends 28 and 32, and that the solder include SnAg 95-5 along with NiTiflux 400. However, any type of compatible solder having the properstrength to bond core materials together could be used, such as otherratios of silver-tin solder, including 90-10, and also gold-tin soldermay be used. Tests show that the joint formed with solder is generallytwice as strong as a joint formed using a hypotube.

[0026] In the embodiment as seen in FIGS. 2, 3, and 10, thecomplementary shape of the connecting ends 28 and 32 is a D-shapecross-section 40. As seen in the cross-sectional view of FIG. 10, theD-shape has a semicircular shape with a straight edge. Othercross-sectional shapes such as ovoids, triangles, trapezoids,rectangles, and similar polygons are contemplated.

[0027]FIG. 2 shows the cantilevered tip 42 of the distal end 28 of theproximal core section 24 which has been formed into a D-shape 40. Theconnecting ends 28 and 32 can be seen in FIG. 3 connected together witheach end having a D-shape cross-section 40. In this embodiment, acantilevered portion 62 of the D-shaped cross-section 40 extendspreferably 1 cm long and transitions into the circular cross-sectionalshape of the proximal core section 24. A transition 60 can be a gradualcurved as shown in FIG. 2, or it may be a step or more angular inprofile. In other embodiments, the length of the cantilevered portion 62can range from 1 mm to 5 cm as needed for optimal design functionality.Naturally, the length of the cantilevered portion 62 influences amountof interfacing surface area available to be welded, bonded, soldered,etc.

[0028] Another embodiment is seen in FIG. 5, where the complementaryshape of the connecting ends 28 and 32 has a D-shaped cross-section 40with a backside 44 on each of the D-shaped ends having a taper 46. Inthis embodiment, the outside diameter of the joint is not constant alongits length, especially at the tips of the proximal end 32 of the distalcore section 30 and distal end 28 of the proximal core section 24. It isalso possible to have only one of the connecting ends 28 or 32 with thetapered backside 46. This design eliminates a potential for the ends to“peel” apart during a tight bend, and provides a more flexible end thateasily bends. In addition, the design of the tapered backside 46 allowsfor a hardened material 36 such as solder to at least partially envelopethe ends 28 and 32, which also reduces peel potential.

[0029] Yet another embodiment is shown in FIG. 6, where the connectingends 28 and 32 include a tapered, D-shaped cross-section 48. The taperin this embodiment is disposed on a front-side 50 of the D-shapecross-section 48, and it is possible for only one of the connecting ends28 or 32 to include this tapered D-shaped cross-section 48. In oneembodiment, the tapered, D-shaped cross-section 48 which is ground intothe connecting ends 28 and 32 is 3 cm in length, although the length mayrange from 1 cm -5 cm. The FIG. 6 embodiment provides a more gradualtransition from the proximal core section 24 to the distal core section30 and therefore is beneficial when using wires with dissimilar bendingforces. It is also conceivable to have another embodiment, where boththe front and back sides of the connecting ends have a taper, such thatthe distal end of the proximal core section has opposed, imaginaryplanes converging in a proximal direction, and the proximal end of thedistal core section has opposed, imaginary planes converging in a distaldirection.

[0030]FIG. 7 shows another embodiment where the connecting ends 28 and32 include a serrated profile 52 at the interface where the ends engage.The serrations 54 provide an alignment geometry that creates improvedjoint strength due to the more complex interface, some frictionalengagement, and additional gaps into which the mass of hardened material36, such as solder, can flow. The serrations 54 improve overall columnstrength at the joint as well as providing good flexibility for bending.These attributes further reduce the potential for the joint to peelapart under stress. This embodiment can also be enhanced by adding ataper 46 on the backside 44 of the serrated D-shaped ends 28, 32 asshown in FIG. 8.

[0031] As seen in FIG. 9, another embodiment has locking serrations 56formed on the connecting ends 28 and 32 that mechanically engage andgrip one another. This embodiment has the attribute of allowing unbondedfitment of the locking serrations 56 before the bonding process, whicheliminates the need for unique alignment fixtures that keep the coresappropriately aligned for soldering or bonding. That is, the serrations56 of the connecting ends 28, 32 have complementary teeth thatmechanically interlock without using any bonding or adhesive agents,which agents are added later to permanently cement the parts to oneanother. The mechanical interlock obviates the need for customizedfixtures, but enables precise alignment of the parts to be joined.

[0032] Next, a method of constructing the above embodiments of thepresent invention guide wire 20 without a hypotube or sleeve will bediscussed. In one embodiment, one of the complementary shapes describedabove or any other complementary shape is formed into the connectingends 28 and 32 by grinding, milling, electrical discharge machining(EDM), laser cutting, or any other appropriate method known in the art.If required, an additional step may be taken where the grind on theconnecting ends 28 and 32 is gold tinned or etched for improvedsolderability. After the connecting ends 28 and 32 have been ground intothe desired shape, the proximal and distal core sections 24 and 30 arethen placed in a fixture in opposing directions with the connecting endsoverlapping each other. The core sections 24 and 30 are placed in thefixture so that there is a small gap 38 between the connecting ends 28and 32 for solder, or other bonding material, to wick into, and thenbond and secure the two core sections together. The solder or otherbonding material may also encase the connecting ends 28 and 32 toprovide a stronger bond. Then, the joined proximal and distal coresections 24 and 30 are ground to a required outer diameter. The actualfinal grind diameter depends upon the design needs of the specific guidewire. Once the final grind is complete, an optional polymer coating maythen be applied to at least a portion of or the entire the core 22. Thefinished guide wire has a smooth cross-sectional profile at the jointfrom the proximal core section 24 to the distal core section 30.

[0033] There are several additional steps that can be taken to improvethe joint integrity of the guide wire 20. If greater bond strength isrequired, the connecting ends 28 and 32 can be plunge ground to asmaller diameter prior to or following the forming of the complementaryshape. For instance, a 0.0130 inch diameter would be plunge ground to0.010 inch. This smaller diameter allows the solder or other bondingmaterial to be applied around the entire circumference of the joinedcores 24 and 30. FIG. 10 shows a cross-sectional view, taken along line10-10 of FIG. 3, of the connecting ends 28 and 32 having D-shapedcross-section 40 which have been plunge ground to a smaller diameter sothe mass of hardened material 36, for example solder, encases the entirecircumferences of the cores 24 and 30. In fact, the D-shapedcross-section 40 is optionally ground to about one half the diameter ofthe guide wire core 22 or slightly less. Also, as already discussed, thebacksides 44 of the complementary shaped connecting ends 28 and 32 canbe ground to form a taper 46. This feature provides a more flexible endthat bends instead of peeling apart, and it allows for more solder toencompass the end.

[0034] To provide a gradual transition form the proximal core to thedistal core, the tapered D-shaped cross-section 40 may be ground intothe connecting ends 28 and 32. Likewise, serrations 54 may be formed bygrinding.

[0035] In yet another method according to the present invention, theconnecting ends 28 and 32 are plunge ground to provide a constant ortapered smaller diameter. In one embodiment, this constant or taperedsmaller diameter is approximately 1 cm long, but may be 0.5 to 5 cmlong. If required, an additional step may be taken where the plungegrind on the ends 28 and 32 is then tinned or etched for improvedsolderability. The plunge ground cores 24 and 30 are then placed in afixture in opposing directions so that the connecting ends 28 and 32overlap one another. Next, solder or other bonding material is appliedalong the overlap to join to the two cores 24 and 30. The joined cores24 and 30 are then ground to a required outer diameter. This final grinddiameter is dependent upon the design needs of the specific guide wire.Once the final grind is complete, a polymer coating may then be appliedto the core 22 or the guide wire 20.

[0036] There is no change to how a guide wire produced with thedisclosed methods is used. The methods described produce a guide wirewith at least two core sections which are joined together without theuse of a hypotube or sleeve. Also these methods may be used to join anytwo wires together, and may even be used to attach a shaping ribbon ontothe distal end of the distal core section, producing a guide wire withtwo lap joints. This embodiment includes at least three core materialsthat are joined or bonded together in the same manner as previouslydescribed for a single lap joint of two core materials. One embodimentwould include a first lap joint connecting together a stainless steelsection with a nitinol section, and the second lap joint connecting thenitinol section with another stainless steel section that can then beformed to act as a shaping ribbon. After the two lap joints are formed,the assembly is ground to appropriate dimensions. Further, any wire canbe formed containing any number of core materials or any number of lapjoints using this method.

[0037] While a particular form of the invention has been illustrated anddescribed, it will also be apparent to those skilled in the art thatvarious modifications can be made without departing from the spirit andscope of the invention. It should be clear that the types of materialused in the core sections may vary. Also, the size and dimensions of theguide wire can vary in terms of outer diameter, ground diameter, length,and ground length. Accordingly, it is not intended that the invention belimited except by the appended claims.

What is claimed is:
 1. An intravascular guide wire, comprising: a corehaving a proximal core section with proximal and distal ends and adistal core section with proximal and distal ends; and a mass ofhardened material at a joint connecting the distal end of the proximalcore section to the proximal end of the distal core section; wherein thejoint is not covered by a sleeve.
 2. The guide wire of claim 1, whereinat least one of the distal end of the proximal core section and theproximal end of the distal core section have a D-shape cross-sectionalshape.
 3. The guide wire of claim 1, wherein a backside of one of thedistal end of the proximal core section and the proximal end of thedistal core section includes a taper.
 4. The guide wire of claim 1,wherein at least one of the distal end of the proximal core section andthe proximal end of the distal core section includes a serration.
 5. Theguide wire of claim 1, wherein at least one of the distal end of theproximal core section and the proximal end of the distal core sectionincludes a rounded cross-section having a straight edge.
 6. The guidewire of claim 1, wherein at least one of the distal end of the proximalcore section and the proximal end of the distal core section includes afront side including a taper.
 7. The guide wire of claim 1, wherein thedistal end of the proximal core section and the proximal end of thedistal core section have locking serrations, and the locking serrationsof the ends grip one another.
 8. The guide wire of claim 1, wherein atleast one of the distal end of the proximal core section and theproximal end of the distal core section includes gold tin disposedthereon.
 9. The guide wire of claim 1, wherein at least one of thedistal end of the proximal core section and the proximal end of thedistal core section has been etched.
 10. The guide wire of claim 1,wherein the mass of hardened material includes a bonding materialselected from the group consisting of: solders, brazes, epoxies, glues,laser welds, or spot welds.
 11. The guide wire of claim 1, wherein themass of hardened material is disposed in-between the distal end of theproximal core section and the proximal end of the distal core section.12. The guide wire of claim 1, wherein the mass of hardened material isdisposed in-between the distal end of the proximal core section and theproximal end of the distal core section encasing the ends.
 13. Anintravascular guide wire having at least two core materials joinedtogether without the use of a hypotube, comprising: a core having aproximal core section with a proximal end and a distal end and a distalcore section with a proximal end and a distal end; the distal end of theproximal core section and the proximal end of the distal core sectionbeing aligned complementary to one another; and a mass of hardenedmaterial disposed between the distal end of the proximal core sectionand the proximal end of the distal core section.
 14. The guide wire ofclaim 13, wherein at least one of the distal end of the proximal coresection and the proximal end of the distal core section have a D-shapecross-sectional shape and a backside of one of the D-shapecross-sectional shape ends includes a taper.
 15. The guide wire of claim13, wherein at least one of the distal end of the proximal core sectionand the proximal end of the distal core section have a D-shapecross-sectional shape including a serration.
 16. The guide wire of claim15, wherein at least one of the distal end of the proximal core sectionand the proximal end of the distal core section includes a rounded crosssection having a straight edge.
 17. The guide wire of claim 13, whereinat least one of the distal end of the proximal core section and theproximal end of the distal core section includes a D-shapedcross-sectional shape including a taper.
 18. The guide wire of claim 13,wherein the distal end of the proximal core section and the proximal endof the distal core section have locking serrations, and the lockingserrations of the ends grip one another.
 19. The guide wire of claim 13,wherein the mass of hardened material includes a bonding materialselected from the group consisting of: solders, brazes, epoxies, glues,or welds.
 20. The guide wire of claim 13, wherein the mass of hardenedmaterial encases the distal end of the proximal core section and theproximal end of the distal core section.
 21. A method for joining twointravascular guide wire core materials without using a hypotube,comprising: providing a proximal core section with a proximal and distalend and a distal core section with a proximal and distal end; forming acomplementary shape into the distal end of the proximal core section andthe proximal end of the distal core section; positioning the proximaland distal core sections in opposing directions; leaving a gapin-between the distal end of the proximal core section and the proximalend of the distal core section; and disposing in the gap a mass ofmaterial joining the proximal and distal core sections together.
 22. Themethod of claim 21, further comprising grinding the joined proximal anddistal core sections to a desired diameter.
 23. The method of claim 21,wherein the complementary shapes include a D-shape.
 24. The method ofclaim 21, further comprising tapering a backside of at least one of thedistal end of the proximal core section and the proximal end of thedistal core section.
 25. The method of claim 21, further comprisingserrating the distal end of the proximal core section and the proximalend of the distal core section.
 26. The method of claim 25, furthercomprising tapering a backside of at least one distal end of theproximal core section and the proximal end of the distal core section.27. The method of claim 21, wherein the complementary shape includes atapered D-shape.
 28. The method of claim 21, wherein the complementaryshaped ends include locking serrations.
 29. The method of claim 28,further comprising engaging the locking serrated ends together.
 30. Themethod of claim 21, wherein the complementary shape is formed by aprocess consisting of: grinding, laser machining, electrical dischargemachining, or chemical etching.
 31. The method of claim 21, furthercomprising gold tinning the complementary shaped ends.
 32. The method ofclaim 21, further comprising etching the complementary shaped ends. 33.The method of claim 21, further comprising plunge grinding the distalend of the proximal core section and the proximal end of the distal coresection prior to forming the complementary shaped ends.
 34. The methodof claim 21, further comprising plunge grinding the distal end of theproximal core section and the proximal end of the distal core sectionafter forming the complementary shaped ends.
 35. A method for joining atleast two intravascular guide wire core materials without using ahypotube, comprising: providing a proximal core section with a proximaland distal end and a distal core section with a proximal and distal end;plunge grinding at least one of the distal end of the proximal coresection and the proximal end of the distal core section; positioning theproximal and distal core sections in opposing directions; leaving anoverlap between the distal end of the proximal core section and theproximal end of the distal core section; applying a hardening materialalong the overlap; and grinding the joined guide wire cores to a desireddiameter.
 36. An intravascular guide wire, comprising: a core having aproximal core section with a proximal end and a distal end and a distalcore section with a proximal end and a distal end; the distal end of theproximal core section and the proximal end of the distal core sectionhaving respective complementary surfaces engaging one another; and meansfor joining the proximal and distal core sections together, withoutusing a sleeve.
 37. An intravascular guide wire, comprising: a corehaving a proximal core section with proximal and distal ends and adistal core section with proximal and distal ends; and a mass ofmaterial having sufficient strength to bond the proximal core section tothe distal core section being disposed at a joint between the distal endof the proximal core section and the proximal end of the distal coresection.
 38. The guide wire of claim 37, wherein the joint has a smoothand constant cross-section from the proximal core section to the distalcore section.
 39. A method for joining at least two intravascular guidewire core materials, comprising: providing a proximal core section witha proximal and distal end and a distal core section with a proximal anddistal end; forming a complementary shape into the distal end of theproximal core section and the proximal end of the distal core section;positioning the proximal and distal core sections in opposingdirections; leaving a gap in-between the distal end of the proximal coresection and the proximal end of the distal core section; and disposingin the gap a mass of material having sufficient strength to bond theproximal core section to the distal core section.